Anti-LPL Antibody from ABM, 100 µg Data Sheet
Antibody Type: Cholesterol Related Antibodies Description: LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]. Immunogen: Human LPL whole protein Specificity: Specifically recognizes Lipoprotein Lipase (LPL) from human and bovine. Tested Applications: WB and ELISA
Application Notes: Western blot (1:100) and ELISA (1:200~500) in lipid metabolic research. Lipoprotein lipase (LPL) is the central enzyme in plasma triglyceride hydrolysis and is secreted by macrophages in the subendothelial space. Evidence has been provided that LPL produced by macrophages in the vessel wall exerts proatherogenic effects. The atherogenic effects of LPL have been mainly attributed to its ability to favor lipid accumulation within macrophages present in the atherosclerotic lesion. Recently, it has also been shown that LPL promotes the development of atherosclerosis through facilitation of monocyte adhesion to endothelial cells, stimulation of tumor necrosis factor alpha (TNF ) secretion, and induction of vascular smooth muscle cell proliferation.
Raised In: Mouse
Clonality: LPL.A4 Isotype: IgG
Storage Buffer: PBS, pH 7.4 with 0.05% sodium azide Formulation: Liquid Concentration: 100 µg/100 µl
Storage: This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. Caution: Anti-LPL Antibody is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.
$205.00
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