Anti-MAD1 Antibody from ABM, 100 µg Data Sheet Antibody Type: Antibody
Description: Mad1 negatively regulates mitosis by preventing cells with misaligned chromosomes from dividing. It is an important target in cancer research because it may sensitize cells to existing chemotherapeutics and its expression may be an indicator of cellular sensitivity to chemotherapy. Mad 1is known to repress Myc target genes and antagonize Myc function.
Immunogen: Recombinant human Mad1
Specificity: Reacts with human Mad1; other species specificity has not yet been determined.
Tested Applications: WB, IF and IP
Application Notes: Titrate for optimal dilution for your application.
Raised In: Mouse
Clonality: P22.9B10.C12
Isotype: IgG2b
Purity: Purified ascites
Storage Buffer: PBS, pH 7.4 with 0.02% sodium azide
Formulation: Liquid
Concentration: 100 µg/100 µl
Storage: This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
References: *Weaver, BA, et al. "Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss," (2003) Journal of Cell Biology, 162: 551-563. [PMID: 12925705]
*Liu ST, Rattner JB, et al. "Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells," (2006) Journal of Cell Biology, 175(1):41-53 [PMID: 17030981]
*Huang H, Feng J, et al. "Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments," (2007) Journal of Cell Biology 7;177(3):413-24 [PMID: 17485487].
Caution: Anti-MAD1 Antibody is for research use only and is not intended for therapeutic or diagnostic applications. Please contact your Territory Manager for more information.
